The Carl Zeiss LSM 710 is a confocal point-scanning microscope able to generate high-resolution three-dimensional images of thick specimens with high sensitivity and low photodamage. It is based on Axio-Observer Z1 inverted microscope body, with motorized XY stage, and has live cell imaging facilities (stage insert for temperature and CO2 control). Applications include timelapse imaging, photobleaching experiments, colocalization studies, spectral detection and 3D imaging.